Metabolic Systemic Effects Triiodothyronine

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Metabolic effects of thyroid hormones in vitro. II. Influence of thyroxine and triiodothyronine on oxidative phosphorylation.

Because of the profound effect of thyroxine on the metabolic rates of animals, several groups of investigators have sought a relationship between this hormone and oxidative phosphorylation (14). The work in this laboratory was designed to test the hypothesis that the thyroid hormone may exert its salutary effects by uncoupling an oxidative phosphorylation just prior to a rate-limiting step in t...

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Effects of Triiodothyronine on Adult Rat Cardiomyocytes

Effects of triiodothyronine (T3) on the expression of cytoskeletal and myofibrillar proteins in adult rat cardiomyocytes (ARC) were followed during two weeks of culture in the presence of 20% T3-depleted (stripped) FCS. Control cultures expressed mainly b -myosin heavy chain (MHC) mRNA. T3 caused a switch to a -MHC expression and a dose-dependent increase of a -smooth muscle ( a -sm) actin mRNA...

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Triiodothyronine radioimmunoassay.

Highly specific antisera to triiodothyronine (T(3)) were prepared by immunization of rabbits with T(3)-bovine serum albumin conjugates. Antisera with T(3) binding capacity of up to 600 ng/ml were obtained. The ability of various thyronine derivatives to inhibit the binding of T(3-) (125)I to anti-T(3) serum was found to vary considerably. l-T(3), d-T(3) and several triiodoanalogues were potent ...

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ژورنال

عنوان ژورنال: The Russian Archives of Internal Medicine

سال: 2020

ISSN: 2411-6564,2226-6704

DOI: 10.20514/2226-6704-2020-10-4-262-271